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Bididi (Biphenyl dimethyl dicarboxylate 25 mg)

Each tablet contains biphenyl dimethyl dicarboxylate 25 mg and excipients q.s. (lactose, corn starch, povidone, CMC calcium, magnesium stearate).

Dosage form

Box of 9 blisters x 10 tablets.

Supportive treatment hepatitis due to virus or chemicals (especially antituberculosis drugs).

This drug is contraindicated in patients with known hypersensitivity to any of active or inactive ingredients.

Caution should be exercised when this drug is administered to patients with chronic active hepatitis or hepatic cirrhosis

Pregnancy and lactation
Pregnancy and nursing mother are forbidden to use.

Adverse effects
Workers exposed to high concentration of biphenyl (up to 128mg/m3) developed toxic symptoms that included irritation of the throat and eyes, headache, nausea, diffuse abdominal pain, numbness, aching of limbs, and general fatigue. One of the workers, who also had somnolence icterus, ascites, and oedema of the legs, died, at autopsy, the liver showed necrosis. Chronic hepatitis was reported in a woman exposed over a 25-year period to biphenyl in the paper used to pack citrus fruit.
The physician should be informed any side effects during the treatment with BIDIDI.

Galic oil (GO) and biphenyl dimethyl dicarboxylate (BDD), comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, effectively prevents acute liver injuries, compared to GO or BDD treatment alone.
Pharmacology and characteristics
Inhibition of liver cell breakdown: Biphenyl dimethyl dicarboxylate inhibits the lipid peroxidation by free radical scavenging action and inhibits covalent binding with hepatotoxic substance which toxic to lipids of microsomes by stabilizing its membrane. Biphenyl dimethyl dicarboxylat markedly improves impaired liver function and relieves the main symptoms of acute or chronic hepatitis.
Protective action against drugs or alcohol: It could be expected that biphenyl dimethyl dicarboxylate has protective action agains liver injury induced by drugs (acetaminophen, antibiotics, antifungal, anticancer drug, pills, etc.) Which widely used in clinical practice or alcohol.

The absorption of biphenyl dimethyl dicarboxylate is about 30% for oral administration. After first pass effect of liver, biphenyl dimethyl dicarboxylate will be metabolized and transformed rapidly. 70% will be excreted from stools. 

Dosage and Administration
Usually administered 1~2 tablets three times daily.
The dose should be appropriately increased according to indication of physician or pharmacist.

36 months.

Store in a dry and cool place (below 30 degree C).

Read leaflet carefully before use
Keep out of reach of children
For more information, consult your physician

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